Individual training programmes for the best results Modern altitude training in a relaxed lying position - MITOVIT® The MITOVIT® is one of the most modern hypoxia training systems on the market, easy to handle and relaxed to use. In addition, you get a quick visual control of the training process and an integrated real-time HRV measurement with display of parasympathetic activity. Features: 18.5 inch full HD touch screen monitor Intuitive software, adapted to the VNS analysis Integrated real-time HRV with display of parasympathetic activity best noise insulation for maximum relaxation remoisturised breathing air for comfortable breathing Integrated oxygen concentrator, no need to replace oxygen cylinders Can be used at rest and during physical exertion Continuous recording of measurement data unlimited storage of training sessions possible simultaneous recording of SPO2 via two pulse oximeters for maximum safety soft, very comfortable to wear pulse oximeters included in the scope of delivery Mobile with swivelling and lockable castors all made in Germany Size (W x H x D): 47.5 cm, 106 cm, 42 cm Weight: approx. 60 kg Financing options MITOVIT® Hypoxic Training device Financing options through Grenke We offer you the following financing options together with our partner Grenke: Financing option A: New purchase value: CHF 22,900 excluding VAT. Down payment CHF 2000.-- Offer data freely selectable from: Term 24 months - instalment excl. VAT CHF 948.85 Term 36 months - instalment excl. VAT CHF 660.45 Term 48 months - instalment excl. VAT CHF 516.25 Term 60 months - instalment excl. VAT CHF 432.65 Purchase option at an imputed residual value of CHF 458. (2% of the purchase price) at the end of the term. This offer is subject to the usual contract and credit checks and is non-binding. All amounts stated in this offer are subject to 7.70% VAT. Financing option B: New purchase value: CHF 22,900 excluding VAT. Down payment CHF 6000.-- Offer data freely selectable from: Term 24 months - instalment excl. VAT CHF 767.25 Term 36 months - instalment excl. VAT CHF 534.05 Term 48 months - instalment excl. VAT CHF 417.45 Term 60 months - instalment excl. VAT CHF 349.85 Purchase option at an imputed residual value of CHF 458. (2% of the purchase price) at the end of the term. This offer is subject to the usual contract and credit checks and is non-binding. All amounts stated in this offer are exclusive of 7.70% VAT. If you are interested, please contact us by telephone on 056 511 76 00 or by e-mail at info@acumax.ch. Payment by instalments through AcuMax Med AG We offer the following instalment payment models: Instalment payment model A: Net acquisition value CHF 22,900 + 500 administration fee Term 6 months - instalments of 3900.-- each This offer is subject to the usual contract and credit checks and is non-binding. All amounts stated in this offer are subject to 7.70% VAT. Instalment payment model B: Net purchase value CHF 22'900.-- + 1004.-- administration fee Term 12 months - instalments of CHF 1992 each This offer is subject to the usual contract and credit checks and is non-binding. All amounts stated in this offer are subject to 7.70% VAT. If you are interested, please contact us by telephone on 056 511 76 00 or by e-mail at info@acumax.ch Standard accessories: 18.5 inch FUll HD touch screen monitor 2 pulse oximeters 5 breathing masks 10 bacteria / virus filters 1 device protection filter 1 breathing tube 1 chest strap, ECG accurate2 mask straps2 contra-angle handpieces Marketing equipment (flyers, posters, videos, graphics for homepage) Practical training Advantages Interval hypoxia normoxia - IHT Interval hypoxia hyperoxia - IHHT Adaptive hyperoxia for best results Best housing insulation for a quiet atmosphere and optimum relaxation during training. Optimum training conditions with the help of the fully automatic hypoxia test. Automatic adjustment of the oxygen supply in biofeedback mode to achieve the optimum training range. Maximum safety thanks to two synchronised pulse oximeters. More efficient training thanks to the unique adaptive hyperoxia. Clearly visualiseswhether the training is in the ideal range. Very mild hypoxia from 18 % O2 for sensitive people. Highest reliability due to pure cable connections of software and hardware. Saves the individual training settingsto enable 100 per cent delegation. Intuitive user interface with capacitive touch display for quick and easy operation. Visualises the altitude metres and the corresponding oxygen concentration for increased compliance. Manufactured to the latest standards in Germany - Made in Germany. Safety MITOVIT® The MITOVIT® Hypoxic Training device offers the highest level of safety in use, thanks to two pulse oximeters. Two values for the SpO2 are always recorded and compared in parallel. Thanks to this double protection, the safety mechanism can intervene and immediately supply the user with normoxic air if one pulse oximeter fails, if the values are incorrect or if there is a difference between the two measurement data. This ensures that the oxygen saturation is not inadvertently lowered below the limit range during treatment. MITOVIT® contains a safety valve which ensures that the supply of room air is guaranteed in the event of a power failure and failure of the device. As everyone's tolerance to hyperoxia is different, the fully automated hypoxia test integrated into the MITOVIT® system should be carried out before the first hypoxia training session in order to determine the individual oxygen concentration. Application Relaxed training - possible with the MITOVIT® Hypoxic Training device! Hypoxic training is best carried out in a semi-recumbent position. The comfortable breathing mask is used to breathe oxygen-poor and oxygen-rich air at intervals to imitate the stimuli of physical exertion. During the training session, you can breathe normally and will not feel short of breath. A session with the MITOVIT® Hypoxic Training device lasts 40 minutes. For athletes who want to increase their performance, hypoxic training can also be used during moderate physical exertion, e.g. on an ergometer. The hypoxia should be set between 18 % and 15 % oxygen. Nobel Prize in Medicine for hypoxia research In 2019, the three scientists Wililam Kaelin, Gregg Semenza and Peter Ratcliffe were awarded the Nobel Prize in Medicine for their research and discovery of molecular mechanisms in the field of cell oxygenation. The cells are able to measure the oxygen content and recognise when adaptation reactions are necessary and in this context the positive reaction of hypoxia. The benefits of hypoxia in accelerating the apoptosis of weakened mitochondria and stimulating the formation of new mitochondria can be utilised with MITOVIT® thanks to its relaxed application.

VNS Analysis Software Software incl. Ipad for analysing the autonomic nervous system Scope of delivery: VNS Analysis Professional iPad 64 GB (pre-installed), WiFi + protective case 2 Creating Health chest straps Permanent free updates VNS Analyse Professional offers everything in one app - heart rate variability, biofeedback and progress monitoring. The VNS Analysis measures all practice-relevant parameters of heart rate variability and the autonomic nervous system. The analysis is divided into HRV and VNS parameters. For the greatest possible certainty in terms of validity and reliability of the values, the VNS analysis is regularly compared with the Kubios HRV scientific software. With the integrated cardiorespiratory biofeedback, the parasympathetic nervous system is stimulated and the reserves can be visualised. The impressive effect of breathing exercises can be shown directly to the patient in a before-and-after comparison. VNS Analysis Professional fulfils all scientific criteria for determining heart rate variability (HRV) and the autonomic nervous system (ANS) contains all relevant and validated parameters for determining HRV and VNS in general practice is the only system to contain validated standard values for adults from worldwide literature is the only system to contain validated paediatric standard values has an ECG accurate recording of 1 ms requires no cables requires little space (table for iPad and chair for patient) has integrated cardiovagal biofeedback (VNS Analyse Professional) has a reliable, fully automatic correction function with an indication of any arrhythmia contains the risk parameter Alpha 1 (DFA 1), which determines the interaction of the individual regulatory systems and thus indicates the quality of regulation provides an immediate evaluation of the measurement for a quick discussion is quick and easy to interpret can be completely delegated has a patient-orientated display with pulse, tension and relaxation enables quick change from patient to therapist view with all parameters Additional orthostasis test module An orthostasis test or position change test is then used. In this test, 130 RR intervals are measured with the patient lying down. This is followed by an acoustic signal and the message: "Stand up now". A further 210 RR intervals are then measured with the patient standing up. The orthostasis test is useful if the parasympathetic values are conspicuously high and the patient's state of mind is characterised by exhaustion and lack of energy. This raises the question of whether there is a regulatory disorder with a hyperactive parasympathetic nervous system and a weakened sympathetic nervous system. The change in position exerts a stress stimulus that can be used to control the switching off of the parasympathetic nervous system. In comparison, a clear difference should be recognisable between the lying and standing position. The heart rate (HR) and the stress index (SI, red bar) should increase, whereas the parasympathetic nervous system (RMSSD, blue bar) should decrease. Additional long-term module The long-term measurement makes it possible to carry out measurements for an unlimited period of time. In addition to displaying the heart rate variability, the parasympathetic activity is visualised in real time as a blue line. Special marker and note functions are also available, which allow individual markers to be created before and during the measurement. This ensures detailed therapy control during the measurement with a clear overview of the effectiveness of the therapeutic interventions on the autonomic nervous system. Additional module IHHT The IHHT (Interval Hypoxia-Hyperoxia Therapy) add-on module makes it possible to measure parasympathetic activity in real time during an IHHT session. As the vegetative system reacts directly and variably to hypoxia, the intensity of the therapy and the duration of the hypoxic and hyperoxic intervals should be adapted to the VNS regulation. In this way, an excessive drop in the parasympathetic nervous system can be avoided and patient safety increased at the same time. In order to be able to assess the changes in parasympathetic activity in the best possible way, the duration of the hypoxia and hyperoxia phases and the number of cycles are set according to the settings of the IHHT device.

Rental device / rental flat rate for 1 month The MITOVIT® Hypoxic Training device can be rented for a monthly flat rate of CHF 1250.–. The price is excluding VAT and plus individually calculated personal delivery and instruction. The MITOVIT® is one of the most modern hypoxia training systems on the market, easy to use and relaxed in application. In addition, you benefit from quick visual monitoring of the training process and an integrated real-time HRV measurement with visualisation of parasympathetic activity. Minimum / Maximum rental period: 3 months Features: 18.5 inch Full HD Touch Screen Monitor Intuitive software, adapted for VNS analysis Integrated real-time HRV with visualisation of parasympathetic activity Best noise insulation for maximum relaxation Rehumidified breathing air for comfortable breathing Integrated oxygen concentrator, no need to replace oxygen cylinders Usable at rest and during physical exertion Continuous recording of measurement data Unlimited storage of trainings possible Recording of SPO2 simultaneously via two pulse oximeters for maximum safety Soft, very comfortable pulse oximeters included in the scope of delivery Mobile with swivel and lockable castors All made in Germany Size (W x H x D): 47.5 cm, 106 cm, 42 cm Weight: approx. 60 kg Standard accessories: 18.5 inch FUll HD Touch Screen Monitor 2 pulse oximeters 5 breathing masks 5 bacteria / virus filters 1 device protection filter 1 breathing hose 1 chest strap, ECG accurate2 mask straps2 angle pieces Marketing starter equipment (flyers, poster, videos, graphics for homepage) Practical training Advantages Interval Hypoxia Normoxia – IHT Interval Hypoxia Hyperoxia – IHHT Adaptive Hyperoxia for best results Best housing insulation for a quiet atmosphere and optimal relaxation during training. Optimal training conditions with the help of the fully automatic hypoxia test. Automatic adjustment of oxygen delivery in biofeedback mode to achieve the optimal training range. Maximum safety thanks to two aligned pulse oximeters. More efficient training due to the unique adaptive hyperoxia. Clearly visualised, whether the training is in the ideal range. Very mild hypoxia from 18% O2 for sensitive individuals. Highest reliability due to pure cable connections between software and hardware. Saves individual training settings, to make 100 percent delegation possible. Intuitive user interface with capacitive touch display for quick and easy operation. Visualises the altitude metres and corresponding oxygen concentration for increased compliance. Manufactured according to the latest standards in Germany - Made in Germany. Safety MITOVIT® The MITOVIT® Hypoxic Training device offers the highest level of safety in use, thanks to two pulse oximeters. Two values for SpO2 are always recorded and compared in parallel. Thanks to this double safeguard, the safety mechanism can intervene and immediately supply the user with normoxic air in the event of a pulse oximeter failure, incorrect values, or if there is a difference between the two measured values. This ensures that the oxygen saturation does not accidentally drop below the limit range during the treatment. MITOVIT® includes a safety valve which ensures that the supply of room air is guaranteed in the event of a power failure or device malfunction. Since tolerance to hyperoxia varies, the fully automated hypoxia test integrated in the MITOVIT® system should be carried out before the first hypoxia training session to determine the individual oxygen concentration. Application Relaxed training – possible with the MITOVIT® Hypoxic Training device! Hypoxic training is best performed in a semi-recumbent position. With the comfortable breathing mask, oxygen-poor and oxygen-rich air is breathed in intervals to simulate stimuli similar to physical exertion. Normal breathing is possible during training sessions and there is no sensation of shortness of breath. One session with the MITOVIT® Hypoxic Training device lasts 40 minutes. For athletes who want to increase their performance, hypoxic training can also be used during moderate physical exercise, e.g. on an ergometer. The hypoxia should be set between 18% and 15% oxygen.      Nobel Prize in Medicine for Hypoxia Research In 2019, the three scientists Wililam Kaelin, Gregg Semenza and Peter Ratcliffe received the Nobel Prize in Medicine for their research and discovery of molecular mechanisms in the field of cellular oxygen supply. The cells are able to measure the oxygen content and detect when adjustment reactions are necessary and in this context the positive reaction to hypoxia. The benefits of hypoxia for accelerating the apoptosis of weakened mitochondria and stimulating the formation of new mitochondria can be utilised with MITOVIT® thanks to relaxing application.

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